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Medicina issued since 1920

Volume 50, Issue 6, 2014

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Articles

Medicina (Kaunas) 2014; 50 (6): 329-33
DOI: 10.1016/j.medici.2014.11.009

Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever.

Akif Acay 1
Memnune Sena Ulu 2
Ahmet Ahsen 1
Gulay Ozkececi 3
Kasim Demir 4
Ufuk Ozuguz 5
Seref Yuksel 2
Gursel Acarturk 4
1 Department of Internal Medicine, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
2 Department of Nephrology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
3 Department of Cardiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
4 Department of Endocrinology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
5 Department of Gastroenterology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
Keywords
Atherogenic index
Atherosclerosis
Familial Mediterranean fever
Inflammation

Numerous inflammatory and innate immune pathways are involved in atherogenesis. We aimed to investigate the atherogenic index and other lipid parameters in individuals with familial Mediterranean fever (FMF), as a predictor of atherosclerosis.
A total of 60 patients with FMF and 60 healthy age- and sex-matched controls were included in this study. The patients with acute infection, chronic metabolic and rheumatic diseases, use of drugs other than colchicine and smoking history were excluded. CRP, ESR, total cholesterol, triglycerides, LDL-C, and HDL-C levels of patients and the control group were measured. Atherogenic index (TG/HDL-C) was calculated.
We found that the atherogenic index values of the patients were significantly higher than those of the control group. HDL-C levels were lower and ESR and TG levels were higher in patients. Total cholesterol, LDL-C and CRP levels did not differ significantly between the two groups. There was no significant difference in the values of total cholesterol, LDL-C, triglycerides (TG), HDL-C, and atherogenic indexes between the groups of patients with and without M694V mutation.
Elaboration of clinical models of inflammation-induced atherogenesis may further advance our knowledge of multiple inflammatory pathways implicated in atherogenesis and provide a useful tool for cardiovascular prevention. We believe that the atherogenic index also be used as a preliminary indication of accelerated atherosclerosis in FMF. However, large-scale prospective studies on this issue are needed.

Received 9 April 2014, accepted 10 November 2014, available online 28 November 2014.

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Atherogenic index as a predictor of atherosclerosis in subjects with familial Mediterranean fever.

(pages: 329-33)
Akif Acay
Memnune Sena Ulu
Ahmet Ahsen
et al.
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