Lietuvos sveikatos mokslų universitetas About Medicina Editorial Office Instructions to Authors Links Online Submission Old site

Medicina issued since 1920

Volume 52, Issue 1,

Browse by category:

  • Abstracts
  • Articles
  • Clinical case reports
  • Guidelines
  • Reviews
  • Previous Issues

Never miss an issue!

Subscribe
Articles

Medicina (Kaunas); 52 (1)
DOI: 10.1016/j.medici.2015.11.008

Effect of probiotics on glucose metabolism in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Qingqing Zhang
Yucheng Wu
Xiaoqiang Fei
Keywords
Diabetes
Glucose
Meta-analysis
Probiotics

Objective

Our aim was to investigate the effects of probiotics on glucose metabolism in patients with type 2 diabetes using a meta-analysis of randomized, controlled trials.

Materials and methods

Online databases Embase, Web of Science, and PubMed were searched until August 2014 to identify eligible articles. Finally, 7 trials were included.

Results

Probiotic consumption significantly changed fasting plasma glucose (FPG) by −15.92 mg/dL (95% confidence interval [CI], −29.75 to −2.09) and glycosylated hemoglobin (HbA1c) by −0.54% (95% CI, −0.82 to −0.25) compared with control groups. Subgroup analysis was conducted to trials with non-yogurts control. Meta-analysis of trials with multiple species of probiotics found a significant reduction in FPG (weighted mean difference [WMD]: −35.41 mg/dL, 95% CI: −51.98 to −18.89). The duration of intervention for ≥8 weeks resulted in a significant reduction in FPG (WMD: −20.34 mg/dL, 95% CI: −35.92 to −4.76). Subgroup analysis of trials with species of probiotics did not result in a significant meta-analysis effect. Furthermore, the duration of intervention <8 weeks did not result in a significant reduction in FPG. The results also showed that probiotic therapy significantly decreased homeostasis model assessment of insulin resistance (HOMA-IR) and insulin concentration (WMD: −1.08, 95% CI: −1.88 to −0.28; and WMD: −1.35 mIU/L, 95% CI: −2.38 to −0.31, respectively).

Conclusions

The present meta-analysis suggests that consuming probiotics may improve glucose metabolism by a modest degree, with a potentially greater effect when the duration of intervention is ≥8 weeks, or multiple species of probiotics are consumed.


Warning: array_filter() expects parameter 1 to be array, null given in /home/webusers/webmedicina/web/medicina/wp-content/themes/lsmu/LSMU/output.php on line 194

Warning: array_filter() expects parameter 1 to be array, null given in /home/webusers/webmedicina/web/medicina/wp-content/themes/lsmu/LSMU/output.php on line 202

Warning: array_filter() expects parameter 1 to be array, null given in /home/webusers/webmedicina/web/medicina/wp-content/themes/lsmu/LSMU/output.php on line 210

Also in this category

Midbody Formation and Fate

(pages: 1-10)
Ieva Antanaviciute
Paulius Gibieža
Rytis Prekeris
et al.

Noninvasive Cerebrovascular Autoregulation Monitoring in Hemodialysis Patients: A Pilot Study

(pages: 7-13)
Arminas Ragauskas
Edita Žiginskienė
Inga Arunė Bumblytė
et al.

Also from this Author

Articles

Effect of probiotics on glucose metabolism in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Qingqing Zhang
Yucheng Wu
Xiaoqiang Fei

Medicina is a peer-reviewed monthly scientific journal of Lithuanian Medical Association, Lithuanian University of Health Sciences and Vilnius University

eISSN 1648-9144

ISSN 1010-660X

2020 © Lithuanian University of Health Sciences, A. Mickevičiaus g. 9, LT 44307 Kaunas.

Tel. +370 37 327229, Faks. +370 37 220733, E-mail: medicina.editor (at) lsmuni.lt

Concept & code – BÜRO