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Articles

Medicina (Kaunas); 52 (1)
DOI: 10.1016/j.medici.2015.11.008

Effect of probiotics on glucose metabolism in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Qingqing Zhang
Yucheng Wu
Xiaoqiang Fei
Keywords
Diabetes
Glucose
Meta-analysis
Probiotics

Objective

Our aim was to investigate the effects of probiotics on glucose metabolism in patients with type 2 diabetes using a meta-analysis of randomized, controlled trials.

Materials and methods

Online databases Embase, Web of Science, and PubMed were searched until August 2014 to identify eligible articles. Finally, 7 trials were included.

Results

Probiotic consumption significantly changed fasting plasma glucose (FPG) by −15.92 mg/dL (95% confidence interval [CI], −29.75 to −2.09) and glycosylated hemoglobin (HbA1c) by −0.54% (95% CI, −0.82 to −0.25) compared with control groups. Subgroup analysis was conducted to trials with non-yogurts control. Meta-analysis of trials with multiple species of probiotics found a significant reduction in FPG (weighted mean difference [WMD]: −35.41 mg/dL, 95% CI: −51.98 to −18.89). The duration of intervention for ≥8 weeks resulted in a significant reduction in FPG (WMD: −20.34 mg/dL, 95% CI: −35.92 to −4.76). Subgroup analysis of trials with species of probiotics did not result in a significant meta-analysis effect. Furthermore, the duration of intervention <8 weeks did not result in a significant reduction in FPG. The results also showed that probiotic therapy significantly decreased homeostasis model assessment of insulin resistance (HOMA-IR) and insulin concentration (WMD: −1.08, 95% CI: −1.88 to −0.28; and WMD: −1.35 mIU/L, 95% CI: −2.38 to −0.31, respectively).

Conclusions

The present meta-analysis suggests that consuming probiotics may improve glucose metabolism by a modest degree, with a potentially greater effect when the duration of intervention is ≥8 weeks, or multiple species of probiotics are consumed.

Also in this category

Abstracts accepted for the Scientific and Practical Conference “MODERN MEDICINE: a NEW APPROACH and RELEVANT RESEARCH” among the medical educational organizations of Kazakhstan, FSU and beyond, confined to the World Osteoporosis Day (WOD) conducted within the framework of NTP AR09563004 “Features of metabolism and the state of bone mineral density in adolescent girls with primary dysmenorrhea”

Abstracts accepted for the International Scientific Conference on Medicine organized within the frame of the 79th International Scientific Conference of the University of Latvia, Riga, Latvia

Also from this Author

Articles

Effect of probiotics on glucose metabolism in patients with type 2 diabetes: A meta-analysis of randomized controlled trials

Qingqing Zhang
Yucheng Wu
Xiaoqiang Fei

Medicina is a peer-reviewed monthly scientific journal of Lithuanian Medical Association, Lithuanian University of Health Sciences and Vilnius University

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