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Volume 52, Issue 1,

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Articles

Medicina (Kaunas); 52 (1)
DOI: 10.1016/j.medici.2015.12.001

Clinical relevance of high sensitivity C-reactive protein in cardiology

Dalia Adukauskienė 1
Aušra Čiginskienė
Agnė Adukauskaitė
Daiva Pentiokinienė
Rimvydas Slapikas 2
Indrė Čeponienė
1 Department of Intensive Care, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2 Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
Keywords
C-reactive protein
Cardiology
High sensitivity C-reactive protein
Ischemic heart disease

Coping with cardiovascular diseases (CVD), which are of the main causes of death worldwide, has influenced investigation of high sensitivity CRP (hsCRP) and its role in pathogenesis, prognosis and prevention of CVD. hsCRP can be synthesized in vascular endothelium, atherosclerotic plaques, and theory of inflammatory origin of atherosclerosis is being more widely debated, raising questions, whether higher hsCRP plasma concentration might be the cause or the consequence. Summing up controversial data from multiple studies, guidelines recommend hsCRP testing for both, primary (stratifying CVD risk groups, selecting patients for statin therapy) and secondary CVD prevention (prognosis of CVD and its treatment complications, evaluation of treatment efficacy in moderate CVD risk group). hsCRP testing also has role in heart failure, atrial fibrillation, arterial hypertension, valve pathology and prognosis of coronary stent thrombosis or restenosis. Medications (the well-known and the new specific – CRP binding) affecting its concentration are being investigated as well.

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