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Medicina issued since 1920

Volume 51, Issue 3, 2015

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Articles

Medicina (Kaunas) 2015; 51 (3): 152-158
DOI: 10.1016/j.medici.2015.05.001

Association of cardio-ankle vascular index with cardiovascular risk factors and cardiovascular events in metabolic syndrome patients

Aleksandras Laucevičius
Ligita Ryliškytė
Jūratė Balsytė
Jolita Badarienė
Roma Puronaitė
Rokas Navickas
Svetlana Solovjova
Keywords
Arterial stiffness
Cardiovascular risk
metabolic syndrome

Objectives

We aimed to investigate the association between arterial stiffness assessed as cardio-ankle vascular index (CAVI) and cardiovascular (CV) risk factors and CV events in the middle-aged metabolic syndrome (MS) patients.

Materials and methods

A follow-up study was carried out in 2106 middle-aged (53.83 ± 6.17 years old, 62% women) MS subjects without overt atherosclerotic disease. Patients were initially recruited in 2009–2011 as participants of the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program and followed up for 3.8 ± 1.7 years for CV events. Thorough cardiometabolic risk assessment was carried out at inclusion.

Results

Subjects with higher CAVI had worse lipid and glucose metabolism profile: elevated total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), decreased high-density lipoprotein cholesterol (HDL-C), higher fasting and oral glucose tolerance test (OGTT) glucose levels (all P < 0.001), and lower fasting insulin (P = 0.021). Greater age (P < 0.001), heart rate (P = 0.016), and mean arterial pressure (P < 0.001) were also associated with higher CAVI. Over the follow-up period, 93 (4.4%) patients developed a cardiovascular event: 55 (2.6%) patients had myocardial infarction and 38 (1.8%) suffered a cerebrovascular event. Fatal CV events comprised 6.5% (n = 6) of all CV events. CAVI was statistically significantly associated with occurrence of myocardial infarction (P = 0.027) and total cardiovascular events (P = 0.045), but not cerebrovascular events (P = 0.65). However, this association was dependent on age and gender.

Conclusions

In the middle-aged MS patients, higher CAVI was associated with altered lipid and glucose metabolism, older age, greater heart rate and mean arterial pressure, and worse cardiovascular outcome.

Received 1 April 2015, accepted 20 May 2014.

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Articles

Association of cardio-ankle vascular index with cardiovascular risk factors and cardiovascular events in metabolic syndrome patients

(pages: 152-158)
Aleksandras Laucevičius
Ligita Ryliškytė
Jūratė Balsytė
et al.
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