Lietuvos sveikatos mokslų universitetas About Medicina Editorial Office Instructions to Authors Links Online Submission Old site

Medicina issued since 1920

Volume 50, Issue 6, 2014

Browse by category:

  • Abstracts
  • Articles
  • Clinical case reports
  • Guidelines
  • Reviews
  • Previous Issues

Never miss an issue!

Subscribe
Articles

Medicina (Kaunas) 2014; 50 (6): 318-22
DOI: 10.1016/j.medici.2014.11.006

How useful is antireflux surgery in lung transplant patients with gastroesophageal reflux?

Victoria Pegna 1
Antanas Mickevičius 2
Clement Tsang 3
1 Bristol Royal Infirmary, Bristol, UK
2 Department of Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
3 St Vincent's Hospital, Sydney, Australia
Keywords
Gastroesophageal reflux disease
Lung transplant
Nissen fundoplication
Proton pump inhibitors
Reflux disease

Respiratory function deteriorates over time after lung transplant. Reflux disease with pulmonary complications is a possible cause of this decline. This case series we aim to assess whether respiratory function improves after Nissen fundoplication in lung transplant patients and if surgery reduces gastroesophageal reflux disease (GERD) symptoms and use of proton pump inhibitors (PPIs).
A retrospective case series of lung transplant patients with reflux disease and Nissen fundoplication. Clinical symptoms, pH-metry data, use of PPIs were recorded before the procedure and up to 18 months postoperatively. The FEV1 values before and after Nissen fundoplication were recorded at 3 monthly intervals. Patients’ satisfaction scores were recorded before operation and postoperatively.
A total of 64 lung transplant patients were selected. After Nissen fundoplication, the pH studies were done on 26 patients. The mean overall acid exposure fraction was 1.03% (P<0.05). FEV1 declined for 6 months postoperatively and then gradually improved. The comparison of FEV1 at 3 months preoperatively to 3 months postoperatively showed no significant difference (P=0.067) as well as at 6 months. A significant improvement in clinical GERD symptoms was achieved after antireflux surgery; however, the patients remained receiving PPIs.
NF has been established as a safe operation for lung transplant patients. Late Nissen fundoplication did not improve lung function significantly amongst lung transplanted patients; however, patients with symptomatic GERD may have benefited from Nissen fundoplication in terms of symptom relief. A multicenter randomized control trial is needed to assess the effect of early unselected reflux control on respiratory function and graft survival.

Received 3 March 2013, accepted 20 November 2014, available online 27 November 2014.

Download Full PDF

Also in this category

Abstracts of the International Scientific Conference on Medicine organized within the frame of the 82nd International Scientific Conference of the University of Latvia Riga, Latvia

Abstracts accepted for the Scientific and Practical Conference “MODERN MEDICINE: a NEW APPROACH and RELEVANT RESEARCH” among the medical educational organizations of Kazakhstan, FSU and beyond, confined to the World Osteoporosis Day (WOD) conducted within the framework of NTP AR09563004 “Features of metabolism and the state of bone mineral density in adolescent girls with primary dysmenorrhea”

Also from this Author

Articles

How useful is antireflux surgery in lung transplant patients with gastroesophageal reflux?

(pages: 318-22)
Victoria Pegna
Antanas Mickevičius
Clement Tsang
Download

Medicina is a peer-reviewed monthly scientific journal of Lithuanian Medical Association, Lithuanian University of Health Sciences and Vilnius University

eISSN 1648-9144

ISSN 1010-660X

2021 © Lithuanian University of Health Sciences, A. Mickevičiaus g. 9, LT 44307 Kaunas.

Tel. +370 37 327229, Faks. +370 37 220733, E-mail: medicina.editor (at) lsmuni.lt

Concept & code – BÜRO