Lietuvos sveikatos mokslų universitetas About Medicina Editorial Office Instructions to Authors Links Online Submission Old site

Medicina issued since 1920

Volume 51, Issue 5, 2015

Browse by category:

  • Abstracts
  • Articles
  • Clinical case reports
  • Guidelines
  • Reviews
  • Previous Issues

Never miss an issue!

Subscribe
Articles

Medicina (Kaunas) 2015; 51 (5): 263-71
DOI: 10.1016/j.medici.2015.08.002

Distribution of CD4(+) and CD8(+) T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking.

Jurgita Jackutė 1
Marius Žemaitis 1
Darius Pranys 2
Brigita Šitkauskienė 1
Skaidrius Miliauskas 1
Vytis Bajoriūnas 3
Raimundas Sakalauskas 1
1 Department of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2 Department of Pathology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
3 Department of Cardiac, Thoracic and Vascular Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
Keywords
CD4+ T cells
CD8+ T cells
Chronic obstructive pulmonary disease
Non-small cell lung cancer
Smoking

The immune system plays an important role in non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the infiltration patterns of CD4(+) and CD8(+) T cells in NSCLC and to analyze their relation to COPD, smoking status and other clinicopathologic variables.
Lung tissue specimens from 50 patients who underwent surgery for NSCLC (stages I-III) and 10 control group subjects were analyzed immunohistochemically.
NSCLC patients had a greater number of CD4(+) and CD8(+) T cells infiltrating the lung tissue than the control group (P=0.001) with predominant infiltration in the tumor stroma. We found a significant association between the number of total and tumor stroma-infiltrating CD4(+) and CD8(+) T cells, and smoking status (P<0.05). There were more CD8(+) T cells in the tumor stroma and fewer in the tumor islets in NSCLC patients with COPD as compared to NSCLC patients without COPD (P<0.05). However, there was no such association between CD4(+) T cells and COPD status. A high level of CD8(+) T cell infiltration in the tumor stroma was independently associated with the coexistence of COPD in multivariate analysis (P<0.05). According to our data, COPD but not smoking seems to be associated with higher infiltration of CD8(+) T cells in the tumor stroma of patients with NSCLC. It allows us to hypothesize that NSCLC patients with coexisting COPD may have a more favorable outcome due to anticancer properties of stromal CD8(+) T cells.

Correspondence to J. Jackutė Department of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, 50161 Kaunas, Lithuania. E-mail address: jjackute@gmail.com

Received 21 May 2015, accepted 31 August 2015, available online 21 September 2015.

Download Full PDF

Also in this category

Abstracts of the International Scientific Conference on Medicine organized within the frame of the 82nd International Scientific Conference of the University of Latvia Riga, Latvia

Abstracts accepted for the Scientific and Practical Conference “MODERN MEDICINE: a NEW APPROACH and RELEVANT RESEARCH” among the medical educational organizations of Kazakhstan, FSU and beyond, confined to the World Osteoporosis Day (WOD) conducted within the framework of NTP AR09563004 “Features of metabolism and the state of bone mineral density in adolescent girls with primary dysmenorrhea”

Also from this Author

Articles

Evaluation of vitamin D levels in allergic and non-allergic asthma.

(pages: 321-7)
Laura Tamašauskienė
Edita Gasiūnienė
Simona Lavinskienė
et al.
Download

Articles

Distribution of CD4(+) and CD8(+) T cells in tumor islets and stroma from patients with non-small cell lung cancer in association with COPD and smoking.

(pages: 263-71)
Jurgita Jackutė
Marius Žemaitis
Darius Pranys
et al.
Download

Medicina is a peer-reviewed monthly scientific journal of Lithuanian Medical Association, Lithuanian University of Health Sciences and Vilnius University

eISSN 1648-9144

ISSN 1010-660X

2021 © Lithuanian University of Health Sciences, A. Mickevičiaus g. 9, LT 44307 Kaunas.

Tel. +370 37 327229, Faks. +370 37 220733, E-mail: medicina.editor (at) lsmuni.lt

Concept & code – BÜRO