Medicina 2002; 38 (1): 63-68
Creation, analysis and antianemic action of peroral powders with ferrous oxalate. Ferosol–1
Palma Nenortienė, Marija Sapragonienė, Antanas Stankevičius¹, Algimantas Petras Matusevičius²,
Gintaras Daunoras²Kaunas University of Medicine, ¹Institute of Cardiology, Kaunas University of Medicine, Lithuania ²Lithuanian Veterinary Academy
Key words: iron-deficiency anemia, antianemic drugs, iron (II) compounds, ferrous oxalate, microelements, stability, chemical analysis, toxicity, local action, iron resorption, antianemic activity.
Summary. Investigation of new stable iron (II) compounds is still an actual problem of today. Therefore we synthesized ferrous oxalate and prepared a stable antianemic powder Ferosol–1 including copper, zinc and cobalt. We used colour tests, precipitation reactions and paper chromatography for identification of components of this powder. Quantitative analysis of iron and other elements was performed using atomic absorption spectroscopy.
We used Lichfield and Wilkinson method modificated by Roth to detect acute Ferosol–1 toxicity. To estimate a local action of this powder we used guinea pigs which were grouped into control and trial ones. We determined bioavailability of Ferosol–1 by giving it to rabbits with experimental posthemorrhagic anemia. Iron resorption was tested on 20–25 days old piglets. We also tried this drug on newborn piglets while atching their weight gain and calculation daily weight gain. This data was used to estimate indirect impact of Ferosol–1 on metabolism of piglets.
According to our data Ferosol–1 is of low toxicity (LD50=2.25 g/kg), it does not irritate mucosa of duodenum and ventriculus and could be used orally. Iron from Ferosol–1 was found to be well assimilated and to take place in hemopoetic processes of rabbit. After administration of Ferosol–1 to piglets iron concentration in their serum increased from 35.03±0.66 to 54.88±6.63
mmol/l, hemoglobin concentration increased to 96.4±2.5 g/l, erythrocyte number increased to 4.4±0.14·1012/l. The same data of control piglets were respectively 83.7±3.1 g/l and 3.52±0.3·1012/l. According to our results Ferosol–1 is an effective drug for prevention of iron-deficiency anemia and causes slight weight gain of piglets.Correspondence to P. Nenortienė, Department of Analytical and Toxicological Chemistry, Kaunas University of Medicine, Mickevičiaus 9, 3000 Kaunas, Lithuania. E-mail: npalma@takas.lt.
Straipsnis gautas 2001 01 31, priimtas 2001 11 15.