Successful treatment with continuous infusion of coagulation factor concentrates in severe hemophilia A complicated with mixed trauma, crush syndrome and acute renal failure

Rasa Griniūtė, Rolandas Gerbutavičius, Vidas Pilvinis¹, Algimantas Pamerneckas²

Clinic of Hematology, ¹Clinic of Intensive Care, ²Clinic of Orthopedics and Traumatology, Kaunas University of Medicine, Lithuania

Key words: hemophilia, continuous infusion, factor concentrate, mixed trauma, acute renal failure.

Summary. Treatment method of hemophilia with continuous infusion of clotting factor concentrates is not widespread. We report our experience with the use of continuous infusion of factor VIII in patient with mixed trauma, crush syndrome and acute renal failure. Patient was successfully treated with fasciotomy of left upper arm and forearm, 6 procedures of hemodialysis, 34.500 units of clotting factor VIII concentrate, and 13 red blood cells units.

Our experience confirms the safety, efficiency, and economy of the method of the constant infusion of clotting factor concentrates for hemophilia patient requiring replacement therapy, surgical intervention, and hemodialysis.

Correspondence to R. Griniūtė, Clinic of Hematology, Kaunas University of Medicine, Eivenių 2, 50009 Kaunas, Lithuania. E-mail: hema@takas.lt

Received 7 July 2004, accepted 7 March 2005